DAVIS G H,MONTGOMERY G W,ALLISON A J,et al.Segregation of a major gene influencing fecundity in progeny of Booroola sheep[J].N Z J Agric Res,1982,25(4):525-529.
 PIPER L R,BINDON B M.The Booroola Merino and the performance of medium Non-Peppin crosses at Armidale[J].Wool Technol Sheep Breed,1983,31(1):14-19,33.
 MULSANT P,LECERF F,FABRE S,et al.Mutation in bone morphogenetic protein receptor-IB is associated with increased ovulation rate in Booroola Mérino ewes[J].Proc Natl Acad Sci U S A,2001,98(9):5104-5111.
 SOUZA C J,MACDOUGALL C,CAMPBELL C,et al.The Booroola (FecB) phenotype is associated with a mutation in the bone morphogenetic receptor type 1 B (BMPR1B) gene[J].J Endocrinol,2001,169(2):R1-R6.
 WILSON T,WU X Y,JUENGEL J L,et al.Highly prolific Booroola sheep have a mutation in the intracellular kinase domain of bone morphogenetic protein IB receptor (ALK-6) that is expressed in both oocytes and granulosa cells[J].Biol Reprod,2001,64(4):1225-1235.
 JUENGEL J L,DAVIS G H,MCNATTY K P.Using sheep lines with mutations in single genes to better understand ovarian function[J].Reproduction,2013,146(4):R111-R123.
 JUENGEL J L,O'CONNELL A R,FRENCH M C,et al.Identification of a line of sheep carrying a putative autosomal gene increasing ovulation rate in sheep that does not appear to interact with mutations in the transforming growth factor beta superfamily[J].Biol Reprod,2011,85(1):113-120.
 HALDAR A,FRENCH M C,BRAUNING R,et al.Single-nucleotide polymorphisms in the LEPR gene are associated with divergent phenotypes for age at onset of puberty in Davisdale ewes[J].Biol Reprod,2014,90(2):33.
 JUENGEL J L,FRENCH M C,O'CONNELL A R,et al.Mutations in the leptin receptor gene associated with delayed onset of puberty are also associated with decreased ovulation and lambing rates in prolific Davisdale sheep[J].Reprod Fertil Dev,2016,28(9):1318-1325.
 INGALLS A M,DICKIE M M,SNELL G D.OBESE,a new mutation in the house mouse[J].Obes Res,1996,4(1):101.
 KENNEDY G C.The role of depot fat in the hypothalamic control of food intake in the rat[J].Proc R Soc Lond B Biol Sci,1953,140(901):578-592.
 ZHANG Y Y,PROENCA R,MAFFEI M,et al.Positional cloning of the mouse obese gene and its human homologue[J].Nature,1994,372(6505):425-432.
 HUMMEL K P,DICKIE M M,COLEMAN D L.Diabetes,a new mutafton in the mouse[J].Science,1966,153(3740):1127-1128.
 TARTAGLIA L A,DEMBSKI M,WENG X,et al.Identification and expression cloning of a leptin receptor,OB-R[J].Cell,1995,83(7):1263-1271.
 COLLINS S,KUHN C M,PETRO A E,et al.Role of leptin in fat regulation[J].Nature,1996,380(6576):677.
 FAROOQI I S,O'RAHILLY S.Leptin:A pivotal regulator of human energy homeostasis[J].Am J Clin Nutr,2009,89(3):980S-984S.
 LEBRETHON M C,VANDERSMISSEN E,GEÉRARD A,et al.In vitro stimulation of the prepubertal rat gonadotropin-releasing hormone pulse generator by leptin and neuropeptide Y through distinct mechanisms[J].Endocrinology,2000,141(4):1464-1469.
 ZIEBA D A,AMSTALDEN M,WILLIAMS G L.Regulatory roles of leptin in reproduction and metabolism:A comparative review[J].Domest Anim Endocrinol,2005,29(1):166-185.
 CHEHAB F F,LIM M E,LU R H.Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin[J].Nat Genet,1996,12(3):318-320.
 SWERDLOFF R S,PETERSON M,VERA A,et al.The hypothalamic-pituitary axis in genetically obese (ob/ob) mice:Response to luteinizing hormone-releasing hormone[J].Endocrinology,1978,103(2):542-547.
 SWERDLOFF R S,BATT R A,BRAY G A.Reproductive hormonal function in the genetically obese (ob/ob) mouse[J].Endocrinology,1976,98(6):1359-1364.
 DONATO J Jr,CRAVO R M,FRAZÃO R,et al.Hypothalamic sites of leptin action linking metabolism and reproduction[J].Neuroendocrinology,2011,93(1):9-18.
DENG Y M,CUI Y L,HU M,et al.Expression of leptin and long-leptin receptor in the female mouse[J].Chinese Journal of Veterinary Science,2010,30(3):414-418. (in Chinese)
ZHANG Y.Research advance on the relationship between leptin and reproduction activities of mammal[J].China Animal Husbandry & Veterinary Medicine,2015,42(7):1836-1841. (in Chinese)
 MCNATTY K P,HEATH D A,CLARK Z,et al.Ovarian characteristics in sheep with multiple fecundity genes[J].Reproduction (Cambridge,England),2017,153(2):233-240.
 DROUILHET L,MANSANET C,SARRY J,et al.The highly prolific phenotype of Lacaune sheep is associated with an ectopic expression of the B4GALNT2 gene within the ovary[J].PLoS Genet,2013,9(9):e1003809.
 CHU M X,LIU Z H,JIAO C L,et al.Mutations in BMPR-IB and BMP-15 genes are associated with litter size in Small Tailed Han sheep (Ovis aries)[J].J Anim Sci,2007,85(3):598-603.
 LIVAK K J,SCHMITTGEN T D.Analysis of relative gene expression data using real-time quantitative PCR and the method[J].Methods,2001,25(4):402-408.
LIU B F.Study on the polymorphism,mRNA expression of leptin and its receptor genes and their association with traits in sheep[D].Taigu:Shanxi Agricultural University,2013. (in Chinese)
 FU Y F,LI L,LI B X,et al.Long form leptin receptor and SNP effect on reproductive traits during embryo attachment in Suzhong sows[J].Anim Reprod Sci,2016,168:57-65.
 卢守亮,李良远,高磊,等.不同品种绵羊发情周期LEPRb mRNA表达分析[J].生物技术通报,2017,33(5):139-144.
LU S L,LI L L,GAO L,et al.The expression of LEPRb mRNA in the estrus cycle of different sheep strains[J].Biotechnology Bulletin,2017,33(5):139-144. (in Chinese)
XIAO X D,DU D C,WANG F,et al.Expression of LEPR gene in the tissues of Guizhou white goat[J].Journal of Mountain Agriculture and Biology,2017,36(1):36-39. (in Chinese)
 SARKAR M,SCHILFFARTH S,SCHAMS D,et al.The expression of leptin and its receptor during different physiological stages in the bovine ovary[J].Mol Reprod Dev,2010,77(2):174-181.
 TU X Y,KUANG Z C,GONG X,et al.The influence of LepR tyrosine site mutations on mouse ovary development and related gene expression changes[J].PLoS One,2015,10(11):e0141800.
 KLEIN K O,MARTHA P M Jr,BLIZZARD R M,et al.A longitudinal assessment of hormonal and physical alterations during normal puberty in boys.Ⅱ.Estrogen levels as determined by an ultrasensitive bioassay[J].J Clin Endocrinol Metab,1996,81(9):3203-3207.
 SMOLINSKA N,KAMINSKI T,SIAWRYS G,et al.Long form of leptin receptor gene and protein expression in the porcine ovary during the estrous cycle and early pregnancy[J].Reprod Biol,2007,7(7):17-39.
 CATTEAU A,CAILLON H,BARRIÈRE P,et al.Leptin and its potential interest in assisted reproduction cycles[J].Hum Reprod Update,2016,22(3):320-341.
 KOSIOR-KORZECKA U,BOBOWIEC R.Leptin effect on nitric oxide and GnRH-induced FSH secretion from ovine pituitary cells in vitro[J].J Physiol Pharmacol,2006,57(4):637-647.